Endocrine Abstracts

Objectives: Adenosine is a purinergic mediator involved in the regulation of many physiological and pathological processes. It acts as neurotransmitter in the central and autonomic nervous system, where it counterbalanaces sympathetic activity. Adenosine is produced by majority of human cellsexerting autocrine, paracrine as well as systemic effects. Due toits vasodilatatory and negative inotropic effects it seems to play a role in ethiopathogenesis of orthostatic intolerance, ...